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Ricardo Alexandre Leitão is a biomedical researcher whose work focuses on the molecular and cellular mechanisms underlying neurovascular dysfunction and neuroimmune signaling. His research integrates experimental and translational approaches to study blood–brain barrier regulation, neuroinflammation, and brain disorders, with a recent emphasis on traumatic brain injury (TBI) and its neurovascular and inflammatory mechanisms.
He obtained his Ph.D. in Biomedical Engineering from the University of Coimbra in 2017, following a Master’s degree in Cellular and Molecular Biology (2012) and a Bachelor’s degree in Biomedical Sciences from the University of Algarve (2010).
His scientific output includes 17 peer-reviewed publications (2 as co-senior authorship) in international journals, predominantly in first-quartile rankings, along with book chapters and ongoing manuscripts in high-impact journals. He has more than 450 citations and an h-index of 10. His work has contributed to advancing knowledge on endothelial–glial interactions, neuropeptidergic signaling, and molecular pathways involved in neurovascular integrity and dysfunction.
He has extensive experience in multidisciplinary research, combining in vitro, in vivo, and human-based studies, and has collaborated with national and international teams. He currently serves as Principal Investigator of two funded projects supported by FCT, focused on neurovascular mechanisms in traumatic brain injury and inflammatory processes.
In his current position at ABC CoLAB (University of Algarve), he contributes to bridging fundamental research and innovation, promoting the translation of laboratory findings into societal and clinical impact, particularly in the context of brain health and neurovascular disorders.
Ricardo Leitão has been actively involved in the supervision and co-supervision of Ph.D. (2 ongoing), Master’s (4 students), and undergraduate students (3 students), as well as in laboratory training (13 students). He has participated in numerous scientific meetings, with multiple oral and poster presentations, and has received several awards for his research contributions.
In addition to his research activities, he contributes to the scientific community as a reviewer for several international journals and is actively engaged in science communication and outreach initiatives.
Atividades
Atividades
2024/09 - Presente. Orientação. Unraveling the Link Between Monocytes Infiltration into the Brain and Methamphetamine Addiction.MSc Biomedical Research (Mestrado). Coorientador.
2024/07 - Presente. Arbitragem científica em revista. Scientific Reports.
2024/07 - Presente. Arbitragem científica em revista. Cell Biology and Toxicology.
2024/02/05 - Presente. Orientação. Final Traineeship entitled: Study the intracellualr mechanisms behind the transmigration of neutrophils through Blood-Brain Barrier in a context of Traumatic Brain Injury.BSc in Biomedical Engineering (Licenciatura/Bacharelato). Orientador.
2024/02/05 - Presente. Orientação. Final Traineeship entitled: Analysis of transcriptomic data from pre-frontal cortex brain samples of chronic stress-exposed animals.BSc in Biomedical Engineering (Licenciatura/Bacharelato). Orientador.
2023/11 - Presente. Arbitragem científica em revista. Journal of Molecular Neurobiology.
2023/10 - Presente. Orientação. Do Patients with Traumatic Brain Injury Have a Melanocortin Receptor 4 Expression that Predicts Mortality and Neuropsychological Dysfunction?.Doctoral Programme in Health Sciences (Doutoramento). Coorientador.
2023/09 - Presente. Orientação. Regulation of prefrontal cortical synaptic function and behavior by chronic stress-induced microRNA-186-5p
upregulation.Experimental Biology and Biomedicine (Doutoramento). Coorientador.
upregulation.Experimental Biology and Biomedicine (Doutoramento). Coorientador.
2023/08 - Presente. Arbitragem científica em revista. Journal of Cellular and Molecular Neurobiology.
2023/03 - Presente. Arbitragem científica em revista. Journal of Neuroinflammation.
2023/02/01 - Presente. Orientação. Deep Learning for animal behavior analysis in psychiatry disorders.Bachelor in Biomedical Engineering (Licenciatura/Bacharelato). Coorientador.
2023/02 - Presente. Arbitragem científica em revista. Neuroscience.
2023/01 - Presente. Arbitragem científica em revista. BMC Psychiatry.
2022/02 - Presente. Arbitragem científica em revista. Journal of Neural transmission.
2021/01 - Presente. Arbitragem científica em revista. Frontiers in Pharmacology.
2020/09 - Presente. Arbitragem científica em revista. Metabolic Brain Disease.
2020/02 - Presente. Arbitragem científica em revista. Neurotoxicology.
2020/01 - Presente. Tutoria. Laboratory Supervision of a PhD Student. Eliane Swely Amador Monteiro Sanches.
2020/01 - Presente. Arbitragem científica em revista. Frontiers in Neuroscience.
2018/11 - Presente. Arbitragem científica em revista. Neuroscience (0306-4522). Elsevier .
2018 - Presente. Arbitragem científica em revista. Journal of Neurochemistry (1471-4159). Wiley (Blackwell Publishing).
Membro de associação. International Society of Neurochemistry.
Membro de associação. FENS (Federation of European Neuroscience Societies).
Membro de associação. British Biochemical Society.
Membro de associação. Sociedade Portuguesa de Neurociências (SPN).
2013 - Presente. Participação em evento. Participation in scientific divulgation related activities, as part of the Program “Brain Awareness Week”. Outro. Brain Awareness Week. Universidade de Coimbra.
2022/10. Entrevista (jornal / revista). Newsletter from Faculty of Medicine, University of Coimbra, focused on internal dissemination of the ongoing research projects. VoiceMed newsletter: Isto e FMUC.
2022/10. Entrevista (jornal / revista). The regional journal made a headline described a FCT funded project, from which I am the PI. Jornal As Beiras.
2022/10. Entrevista (jornal / revista). One of the biggest online journals in Portugal write a text in the subsection of science describing the FCT-funded project that aims to uncover new therapeutic targets to treat traumatic brain injury, and from which I am the PI.. Observador.
2024/10. Júri de grau académico. Unravelling the Effects of Osteosarcoma-Derived Secretome in Cardiac Endothelial Cell Dysfunction. Arguente principal. Nuno Miguel Martins de Aquino (Mestrado). Universidade de Coimbra Faculdade de Medicina.
2023/09 - 2024/09. Orientação. Exploring the Role of CCR5 in Methamphetamine-Induced Neurovascular Alterations.MSc in Biomedical Research (Mestrado). Coorientador.
2023/01/18. Apresentação oral de trabalho. Traumatic brain injury: a vascular point of view. DCV Talks. Universidade de Coimbra, Departamento de Ciências da Vida (Coimbra, Portugal).
2024/07. Júri de grau académico. Interindividual Differences in Nicotine Vulnerability. Arguente principal. Luke Charles Westlake (Mestrado). Universidade de Coimbra Faculdade de Medicina.
2024/07. Júri de grau académico. Unraveling Neurovascular Dysfunction in Machado-Joseph Disease: Mesenchymal Stromal Cells as a Promising Therapy. Vogal. Maria Inês Veiga de Almeida Barros (Doutoramento). Universidade de Coimbra Instituto de Investigação Interdisciplinar.
2024/06. Júri de grau académico. The effects of early-life stress and MeCP2 interaction on neurobehavior. Arguente principal. Carolina Oliveira Silva (Outro). Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia.
2024/05 - 2024/05. Curso / Disciplina lecionado. Practical Classes of Methods and Techniques in Molecular Biology, from BSc of Biology. Biology (Licenciatura). Universidade de Coimbra Faculdade de Ciencias e Tecnologia.
2024/02. Júri de grau académico. Unravel the Role of Pericytes in Endothelial Cell Dysfunction Induced by Brain Metastatic Breast Cancer Cells. Arguente principal. Maria Eduarda Fernandes Lopes (Mestrado). Universidade de Coimbra Faculdade de Medicina.
2022/09/01 - 2023/10/31. Orientação. Crosstalk between neutrophils and endothelial cells in a context of traumatic brain injury: Role of CXCL8-CXCR2 axis.Master in Biomedical Research (Mestrado). Orientador.
2023/02/01. Apresentação oral de trabalho. Blood-brain barrier dysfunction in the context of traumatic brain injury: a door to neutrophils transmigration?. 53rd Meeting of the Pharmacology Portuguese Society.
2022/02/09. Apresentação oral de trabalho. Unveilling the effects of Methylphenidate on the retina of Control and Attention-Deficit/Hyperactivity Disorer rat models. SPF Meeting 2022 - Sociedade Portuguesa de Farmacologia (Portuguese Society of Pharmacology).
2021/12/18 - 2021/12/18. Curso / Disciplina lecionado. Collaborator as a lecturer in the advanced course “Psychotic Disorders and Addiction”, under the theme “Neurobiology of Addiction”, of the Master’s in Applied Pharmacology. Psychotic Disorders and Addiction (Mestrado). Universidade de Coimbra Faculdade de Farmácia.
2021/11/01 - 2021/12/03. Organização de evento. Member of Organization of “XVII Meeting of the Portuguese Society for Neuroscience” (2021). Sociedade Portuguesa de Neurociências.
2021/02 - 2021/07. Tutoria. Laboratory Supervision of BSc final traineeship. Amélia Ormonde.
2021/01 - 2021/07. Tutoria. Laboratory Supervision of BSc final traineeship. Beatriz Marques.
2018/01 - 2021/07. Tutoria. Laboratory Supervision of a PhD thesis. José Luis Alves.
2021/04/15 - 2021/04/15. Curso / Disciplina lecionado. Collaborator as a lecturer in the advanced course “Cerebral-Vascular Diseases and Epilepsy”, under the theme “Pathological mechanisms in Stroke”, of the Master’s in Molecular and Translational Neuroscience, Faculty of Medicine, University of Coimbra. Cerebral-Vascular Diseases and Epilepsy (Mestrado). Universidade de Coimbra Faculdade de Medicina.
2020/07/01 - 2021/02/28. Tutoria. Laboratory Supervision of BSc final traineeship from University of Utrecht. Dunya Selemangel.
2021/02/17. Apresentação oral de trabalho. Impact of Methylphenidate on the retina in control and ADHD conditions . SPF Meeting 2021 - Sociedade Portuguesa de Farmacologia (Portuguese Society of Pharmacology).
2019/09 - 2020/09. Tutoria. Laboratory Supervision of a Master thesis. Mariana Muga.
2020/01 - 2020/07. Tutoria. Laboratory Supervision of BSc final traineeships. Leandro Várzeas.
2020/02. Apresentação oral de trabalho. Impact of traumatic brain injury on astrocytes: role of neuropeptide Y. L Meeting of Portuguese Society of Pharmacology, XXXVIII Meeting of Clinical Pharmacology, XIX Meeting of Toxicology. Portuguese Society of Pharmacology (Portugal).
2018/09 - 2019/07. Orientação. Traumatic brain injury impact on astrocytes-endothelial cells crosstalk: Role of Neuropeptide Y.Master in Biomedical Research (Mestrado). Coorientador.
2018/09 - 2019/07. Tutoria. Laboratory Supervision of a Master thesis. João Novo.
2019/05/10. Apresentação oral de trabalho. Neurovascular alterations induced by methylphenidate: attention deficit and hyperactivity disorder versus control. 1st Retreat of CIBB.
2019/02 - 2019/03. Organização de evento. Participation in scientific divulgation related activities, as part of the Program “Brain Awareness Week” with kindergarten children (2019).
2018/10 - 2018/11. Organização de evento. Participation in scientific divulgation related activities, as part of the “Semana C&T 2018”, with visits to kindergarten and high-school students visiting the labs (2018).
2018/08 - 2018/09. Organização de evento. Participation in activities (Guerra das Cores) as part of the European Researchers’ Night, Botanical Garden, University of Coimbra (2018).
2018/05. Apresentação oral de trabalho. De olho na PHDA: pode a retina servir de apoio ao diagnóstico? (Keeping an eye on ADHD: can the retina support the diagnosis?). 1º Congresso Nacional de PHDA.
2018/02 - 2018/04. Organização de evento. Participation in scientific divulgation related activities, as part of the Program “Brain Awareness Week” (2018).
2018/02. Apresentação oral de trabalho. Parthenolide as a new protective approach against neurovascular unit dysfunction induced by methamphetamine. XLVIII Meeting of Portuguese Society of Pharmacology. Sociedade Portuguesa de Farmacologia (Lisboa, Portugal).
2017 - 2018. Tutoria. Laboratory Supervision of a Master thesis. Fabiana Ventura.
2017/08 - 2017/09. Organização de evento. Participation in activities (Uma Noite com Sentidos) as part of the European Researchers’ Night, Science Museum of the University of Coimbra (2017).
2016/09 - 2017/08. Tutoria. Laboratory Supervision of a master thesis. Teresa Lourenço.
2017/01 - 2017/02. Organização de evento. Organization of “XLVII Annual Meeting of Portuguese Society of Pharmacology” (2017).
2017. Apresentação oral de trabalho. Can parthenolide prevent methamphetamine-induced neurovascular dysfunction?. XLVII Meeting of Portuguese Society of Pharmacology. Sociedade Portuguesa de Farmacologia (Coimbra, Portugal).
2017. Apresentação oral de trabalho. Brain immune response triggered by early developmental chronic consumption of methylphenidate: control vs attention-deficit/hyperactivity disorder rat model. 16th European School of Neuroimmunology (ESNI) and XXVI Congress of Italian Association of Neuroimmunology (AINI). Italian Association of Neuroimmunology (Itália).
2017. Apresentação oral de trabalho. Impact of chronic methylphenidate administration in rat brain immune surveillance: control versus ADHD. XLVII Meeting of Portuguese Society of Pharmacology, XXXV Meeting of Clinical Pharmacology and XVI Meeting of Toxicology. Portuguese Society of Pharmacology (Portugal).
2017. Apresentação oral de trabalho. Role of moderate and intense exercise on blood-brain barrier properties. 10th European Congress of EFSMA.
2016/04 - 2016/11. Tutoria. Laboratory Supervision of a PhD thesis. Cristhyane Costa de Aquino.
2016/02 - 2016/03. Organização de evento. Participation in scientific divulgation related activities, as part of the Program “Brain Awareness Week” (2016).
2015 - 2016. Tutoria. Laboratory Supervision of a Master thesis. Vitor Pinheiro.
2015 - 2016. Participação em evento. International Federation of Medical Students' Associations (IFMSA) program that allows medical students from all over the world discover new realities and new MD schools. Further, it shows them how science is made in a country different from their own. Oficina (workshop). International Federation of Medical Students' Associations.
2015/02 - 2015/03. Organização de evento. Participation in scientific divulgation related activities, as part of the Program “Brain Awareness Week” (2015).
2015. Apresentação oral de trabalho. Blood-brain barrier dysfunction and neuroinflammation triggered by chronic methamphetamine self-administration in rats. VII Annual Meeting of IBILI. Faculty of Medicine, University of Coimbra (Coimbra, Portugal).
2015. Apresentação oral de trabalho. Methamphetamine induces brain edema and blood-brain barrier disruption by aquaporin 4 via protein kinase C pathway.. XLV Meeting of Portuguese Society of Pharmacology. Sociedade Portuguesa de Farmacologia (Lisboa, Portugal).
2015 - 2015. Tutoria. Laboratory Supervision of BSc final traineeships. Ana Rita Mendes.
2015 - 2015. Tutoria. Laboratory Supervision of BSc final traineeships. Rute Gonçalves.
2014/10 - 2014/11. Organização de evento. Participation in scientific activity "Vem Fazer Muita Ciência (Vem à FMUC)"-Semana C&T2014 (2014).
2014/02 - 2014/03. Organização de evento. Participation in scientific divulgation activity as part of the Program “Brain Awareness Week (2014).
2014. Apresentação oral de trabalho. Brain edema and blood-brain barrier breakdown induced by methamphetamine: role of aquaporin 4. “Cellular Biology of Addiction” Summer Course. University Pompeu Fabra, Spain, partnered with the Cold Spring Harbor Laboratory, USA (Barcelona, Espanha).
2014. Apresentação oral de trabalho. Methamphetamine induces alterations in brain water homeostasis: role of aquaporin 4.. XLIV Meeting of Portuguese Society of Pharmacology. Sociedade Portuguesa de Farmacologia (Coimbra, Portugal).
2013/01 - 2013/06. Curso / Disciplina lecionado. Practical classes of Master of Experimental Pathology. Instituto Biomédico de Investigação em Luz e Imagem.
2013. Apresentação oral de trabalho. Methamphetamine-induced blood-brain barrier dysfunction: role of tumour necrosis factor-alpha.. V Annual Meeting of IBILI. Faculty of Medicine, University of Coimbra (Coimbra, Portugal).
2012 - 2013. Tutoria. Laboratory Supervision of a Master thesis. Tânia Capelôa.
Membro de associação. Nucleo Estudantes Ciencias Biomedicas, Universidade do Algarve.
Projetos
Projetos
2025/10/01 - Presente. therapY - O sistema do neuropeptídeo Y como um novo alvo terapêutico para o traumatismo cranioencefálico. [therapY - Neuropeptide Y system as a new therapeutic target against Traumatic Brain Injury], MPr-2023-12 - SACCCT - Projetos de IC&DT. Investigador responsável. Universidade de Coimbra Faculdade de Medicina.
2025/07 - Presente. Blood-Brain Crosstalk in Drug Addiction: CCR5 as a promising therapeutic target . Investigador. Universidade de Coimbra Faculdade de Medicina.
2024/10/01 - Presente. BREATHE: Blocking Respiratory Exacerbations: AI and data-driven Technology for Health Enhancement. Investigador.
2022/04/01 - Presente. Regulation of prefrontal cortical synaptic function and behavior by chronic stress-induced microRNA-186-5p. Investigador. Universidade de Coimbra Centro de Neurociências e Biologia Celular.
2021/01/01 - 2025/12/31. Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado, 6817 - DCRRNI ID. Universidade de Coimbra; Universidade Nova de Lisboa Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação; Universidade de Coimbra Centro de Neurociências e Biologia Celular.
2022/01/01 - 2023/12/31. Neutrophils infiltration through blood-brain barrier in traumatic brain injury: Role of CXCL8. Investigador responsável. Universidade de Coimbra.
2020/01 - 2023/12. Strategic Project Center for Innovative Biomedicine and Biotechnology. Investigador.
2021/09 - 2023/08. Cerebrovascular hypothesis of stress-induced behavioral alterations. Investigador.
2022/01/01 - 2023/06/30. Infiltração de neutrófilos através da barreira hemato-encefálica no traumatismo crânio-encefálico: papel da CXCL8, 3599-PPCDT. Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra.
2018/01/03 - 2021/12/31. BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias. Bolseiro de Pós-Doutoramento. CNC.IBILI.
2015 - 2021. Neuropeptide response in Traumatic Brain Injury - study in an animal model of trauma. Universidade de Coimbra Faculdade de Medicina.
2019/01 - 2019/12. CNC. IBILI, 6817 - DCRRNI ID. Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde.
2017/02/01 - 2018/02/28. Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy. Bolseiro de Investigação. CNC.IBILI.
2013/06/01 - 2015/09/30. O metilfenidato e as alterações na barreira hemato-encefálica numa situação fisiológica e na perturbação de hiperatividade com défice de atenção (Methylphenidate and changes in the blood-brain barrier in a physiological situation and in attention deficit hyperactivity disorder), 5876-PPCDTI. Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular.
2013/06 - 2015/09. Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder. Outra.
2013/01/01 - 2014/12/31. Projecto Estratégico - UI 3282 - 2013-2014, Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2013 - COMPETE. Universidade de Coimbra.
2011/01/01 - 2012/12/31. Projecto Estratégico - UI 3282 - 2011-2012, Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2011 - COMPETE. Universidade de Coimbra.
Produções
Leitão, Ricardo Alexandre; Alves, José Luis; Ana Luisa Bernardo; Silva, Ana Paula. 2026. "Beneficial effect of intranasally neuropeptide Y administration against traumatic brain injury outcomes: a two-sided story".
Oliveira, Raul; Rodrigues, Beatriz; Leitão, Ricardo Alexandre; Silva, Mariline; Pinheiro, Paulo Silva; Carvalho, Ana Luisa. Autor correspondente: Carvalho, Ana Luisa. 2025. "Shaping the synapse through neuronal activity-regulated miRNAs". Trends in Neurosciences. https://doi.org/10.1016/j.tins.2025.06.001
Sanches, Eliane S.; Leitão, Ricardo A.; Baptista, Filipa I.; Mota, Sandra I.; Caldeira, Margarida V.; Oliveira, Paulo J.; Ambrósio, António F.; Fernandes, Rosa; Silva, Ana P.. 2025. "Methylphenidate triggers retinal oxidative stress and mitochondrial dysfunction under physiological conditions but has beneficial effects in inflammatory settings". Neuropharmacology, 279. https://doi.org/10.1016/j.neuropharm.2025.110623
Carvalho, Rita; Santos, Liliana; Conde, Inês; Ricardo A Leitão; Ferreira, Hugo RS; Gomes, Célia; Silva, Ana Paula; et al. Autor correspondente: Ribeiro, Ana Sofia. 2024. "Nerve growth factor inducible (VGF) is a secreted mediator for metastatic breast cancer tropism to the brain". The Journal of Pathology, 264 (2): 132-147. https://doi.org/10.1002/path.6319
Rodrigues, Beatriz; Ricardo A Leitão; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela S.; Abreu, Mónica; et al. 2024. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". Molecular Psychiatry. https://doi.org/10.1038/s41380-024-02715-1
Sanches, Eliane Swely; Boia, Raquel; Maria H. Madeira; Leitão, Ricardo Alexandre; Baptista, FI; António Francisco Rosa Gomes Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. 2024. "Unveilling the impact of methylphenidate misuse on the retina". Trabalho apresentado em 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology, Lisbon, Portugal.
Sanches, Eliane S.; Boia, Raquel; Leitão, Ricardo A.; Madeira, Maria H.; Fontes-Ribeiro, Carlos A.; Ambrósio, António Francisco; Fernandes, Rosa; Silva, Ana Paula. 2023. "Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterations and Methylphenidate Has a Differential Effect in ADHD versus Control Conditions". Antioxidants, 12 (4). https://doi.org/10.3390/antiox12040937
Nóbrega, Laura; Alves, José Luis; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD; Ricardo A Leitão. Autor correspondente: Ricardo A Leitão. 2023. "Blood-brain barrier dysfunction in the context of traumatic brain injury: A door to neutrophils transmigration?". Trabalho apresentado em 53rd Meeting of the Pharmacology Portuguese Society, Coimbra, Portugal.
Nóbrega, Laura; Alves, José Luis; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD; Ricardo A Leitão. Autor correspondente: Ricardo A Leitão. 2023. Blood-Brain Barrier dysfunction after traumatic brain injury: A clear way for neutrophils transmigration. Em FENS Featured Regional Meeting.
Maria Francisca Madeira; Masella, Gianluca; Francisca Silva; Ricardo A Leitão; M Abellán-Álvaro; A Teruel; Agustín-Pavón, Carmen; Monica Santos. 2023. Early-life stress and MeCP2 interaction effects on anxiety neurocircuitry. Em FENS Featured Regional Meeting.
2023. Mice model of chronic unpredictable stress. chronic model of stress that induced anxiety, depression and cognitive impairments.
Novo, João P.; Muga, Mariana; Lourenço, Teresa; Sanches, Eliane S.; Ricardo A Leitão; Silva, Ana Paula. 2023. "Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies". Toxicology Letters, 389: 1-10. https://doi.org/10.1016/j.toxlet.2023.10.008
Rodrigues, Beatriz; Leitão, Ricardo Alexandre; Santos, Monica; Silva, Mariline; Paulo César Silva Pinheiro; Carvalho, Ana Luisa. 2023. REGULATION OF PFC SYNAPTIC FUNCTION AND BEHAVIOR BY CHRONIC STRESS-INDUCED MICRORNA-186-5P. Em FENS Regional meeting 2023.
Ricardo A Leitão; Alves, José Luis; Ana Luisa Bernardo; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD. Autor correspondente: Ricardo A Leitão. 2022. "Role of neuropeptide Y on neurovascular alterations induced by traumatic brain injury". Trabalho apresentado em I International Meeting on the Brain Vasculature, Portugal.
Alves, José Luis; Doutora Ana Paula Silva, IBILI, Faculty of Medicine, University of Coimbra; Leitão, Ricardo Alexandre; Pinto, Anabela Mota. 2022. "Neuropeptide response in traumatic brain injury". Trabalho apresentado em 39th Annual Symposium of the National Neurotrauma Society, including the AANS/CNS Joint Section on Neurotrauma and Critical Care, Atlanta, Estados Unidos, 39 (11-12).
Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo Alexandre; Maria Helena Bica Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Ambrósio; Rosa Cristina S Fernandes; Ana Paula Silva. 2022. A pre-clinical study to analyze the retinal alterations in Attention Deficit/Hyperactivity Disorder (ADHD) and the effect of methylphenidate. Em 5th National Congress of ADHD (5º Congresso Nacional PHDA).
Sanches, Eliane Swely; Boia, R.; Leitão, Ricardo Alexandre; Maria Helena Bica Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Rosa Gomes Ambrósio; Rosa Cristina S Fernandes; Ana Paula Pereira da Silva Martins. 2022. Retinal alterations in Attention-deficit/Hyperactivity Disorder and control conditions with(out) methylphenidate treatment . Em 35th ECNP Congress.
Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo Alexandre; Carlos Alberto Fontes Ribeiro; António Francisco Rosa Gomes Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. 2022. "Unveilling the effects of Methylphenidate on the retina of control and Attention-Deficit/Hyperactivity Disorder rat models". Trabalho apresentado em 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology, Porto, Portugal.
Sanches, ESAM; Boia, Raquel; Leitão, Ricardo Alexandre; Madeira, Maria; Fontes-Ribeiro, Carlos A; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins, PhD. 2021. Retinal physiology and function in control and ADHD conditions with(out) methylphenidate treatment. Em XVII Meeting of the Portuguese Society for Neuroscience.
Leitão, Ricardo Alexandre; Alves JL; Bernardo AL; Fontes-Ribeiro CA; Silva AP. 2021. Microglial and astrocytic responses after traumatic brain injury: role of neuropeptide Y. Em XVII Meeting of the Portuguese Society for Neuroscience.
Leitão, Ricardo Alexandre; Alves JL; Bernardo AL; Fontes-Ribeiro CA; Silva AP. 2021. Impact of traumatic brain injury on blood-brain barrier properties: role of neuropeptide Y. Em Virtual Symposium "Signal Transduction at the Blood-Brain Barriers.
Leitão, Ricardo Alexandre; Alves, José Luís; Bernardo, Ana Luisa; Fontes-Ribeiro, Carlos; Doutora Ana Paula Silva, IBILI, Faculty of Medicine, University of Coimbra. 2021. "Impact of traumatic brain injury on blood–brain barrier properties: role of neuropeptide Y". Trabalho apresentado em “Signal Transduction at the Blood–Brain Barriers” published in Fluids and Barriers of the CNS , 18 (1).
Ricardo A Leitão; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. Autor correspondente: Silva, Ana Paula. 2021. "The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations". European Journal of Clinical Investigation, 52 (4). https://doi.org/10.1111/eci.13694
Santos, L; Carvalho, R; Ricardo A Leitão; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. 2021. Breast cancer secreted VGF-derived peptide TLQP-21 compromises the blood-brain barrier integrity. Em Porto Cancer Meeting.
Ventura, Fabiana; Muga, Mariana; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Leitão, Ricardo A.; Silva, Ana Paula. 2020. "Protective effect of neuropeptide Y2 receptor activation against methamphetamine-induced brain endothelial cell alterations". Toxicology Letters, 334: 53-59. https://doi.org/10.1016/j.toxlet.2020.09.013
Ricardo Alexandre Leitão; Ana Paula Pereira da Silva Martins, PhD. 2020. "The impact of drugs of abuse on blood-brain barrier". Em Advances in Brain Vascular Research.
Liliana Santos; RIta Carvalho; Ricardo Alexandre Leitão; Ana Sofia Ribeiro; Joana Paredes; Ana Paula Silva; Célia Gomes. 2020. VGF-secreted peptidederived from brain metastatic breast cancer cells interferes with blood-brainbarrier properties. Em EACR-AACR Basic and Translational Research Conference in partnership with ASPIC Tumor Microenvironment.
Alves, José Luís; Mendes, João; Leitão, Ricardo; Silva, Ana Paula; Pinto, Anabela Mota. 2020. "A multi-staged neuropeptide response to traumatic brain injury". European Journal of Trauma and Emergency Surgery. https://doi.org/10.1007/s00068-020-01431-z
Liliana Santos; Rita Carvalho; Ricardo Alexandre Leitão; Ana Sofia Ribeiro; Joana Paredes; Ana Paula Pereira da Silva Martins, PhD; Célia Gomes. 2020. VGF-secreted peptide derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties. Em EACR-AACR Basic and Translational Research Conference in partnership with ASPIC.
Liliana Santos; Rita Carvalho; Ricardo Alexandre Leitão; Ana Sofia Ribeiro; Joana Paredes; Ana Paula Pereira da Silva Martins, PhD; Célia Gomes. 2020. The VGF-derived peptide TLQP-21 released by breast cancer cells promotes the loss of brain endothelial cell monolayer integrity. Em CANCER BIOLOGY: FROM BASIC TO TRANSLATIONAL RESEARCH webinar.
Sanches, ESAM; Boia, Raquel; Leitão, Ricardo Alexandre; Martins, Joao; Fontes-Ribeiro, Carlos A; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins, PhD. 2020. Impact of Methylphenidate on the Retina in Control and ADHD conditions. Em SPF Meeting 2020 - Sociedade Portuguesa de Farmacologia (Portuguese Society of Pharmacology).
de Aquino, Cristhyane C.; Leitão, Ricardo Alexandre; Oliveira Alves, Luís A; Coelho-Santos, V.; Guerrant, Richard L.; Fontes-Ribeiro, Carlos A.; Malva, João O.; Silva, Ana P.; Oriá, Reinaldo B.. 2019. "Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress". Frontiers in Nutrition, 5 (131). https://doi.org/10.3389/fnut.2018.00131
Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo A.; Gomes, Célia; Rito, Manuel; et al. 2019. "Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats". European Neuropsychopharmacology, 29 (2): 195-210. https://doi.org/10.1016/j.euroneuro.2018.12.007
Bernardo, Ana Luisa; Leitão, Ricardo Alexandre; Alves, José Luis; Fontes-Ribeiro, Carlos A; Silva, Ana Paula. 2019. Effect of traumatic brain injury in vitro model on astrocytes function: role of neuropeptide Y. Em IV Symposium PT Glial Network.
Leitão, Ricardo Alexandre; Alves, José Luis; Bernardo, Ana Luisa; Fontes-Ribeiro, Carlos A; Silva, Ana Paula. 2019. Impact of traumatic brain injury on astrocytes: role of neuropeptide Y. Em XIV European Meeting on Glial Cells in Health and Disease.
Leitão, Ricardo Alexandre; Alves, José Luis; Bernardo, Ana Luisa; Fontes-Ribeiro, Carlos A; Silva, Ana Paula. 2019. "Impact of traumatic brain injury on astrocytes: role of neuropeptide Y". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal.
Ana Luisa Bernardo; Ricardo Alexandre Leitão; José Luís Alves; Carlos A Fontes-Ribeiro; Ana Paula Silva. 2019. Role of neuropeptide Y in astrocytic alterationsinduced by traumatic brain injury: in vitro study. Em IVPortuguese Glial Networking, Glia Diversity in Neuromodulation and Neurodegeneration..
RIta Carvalho; Inês Cônde; Liliana Santos; Ricardo Alexandre Leitão; Célia Gomes; Ana Paula Silva; Joana Paredes; Ana Sofia Ribeiro. 2019. "Characterization of the secretome profile in brain metastic breast cancer cells". Trabalho apresentado em 2nd joint EACR-MRS conference - Seed and Soil: mechanisms of metastasis, Berlin, Alemanha, 55.
Silva, Ana Paula; Madeira, Maria H.; Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Boia, Raquel; Fontes-Ribeiro, Carlos A.; Fernandes, Rosa. 2019. An eye on ADHD: Can the retina be used as a diagnostic support tool?. Em 7th World Congress on ADHD.
Novo, João Pedro; Santos, Liliana; Leitão, Ricardo Alexandre; Fontes Ribeiro CA; Rosa Cristina Simões Fernandes; Ana Paula Pereira da Silva Martins. 2019. Effect of methylphenidate on microglia: an in vitro study. Em 1st Annual Meeting in Pharmaceutical Sciences,.
Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. 2019. Secretome derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties . Em CIBB Meeting .
Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Silva, Ana Paula; Gomes, Célia; Paredes, Joana; Ribeiro, Ana Sofia. 2019. Deciphering the specifically enriched signature associated with breast cancer brain metastasis. Em 2nd Joint EACR-MRS Conference. Seed and Soil-In vivo Models of metastasis.
Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo A.; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. 2018. "Impact of developmental exposure to methylphenidate on rat brain’s immune privilege and behavior: Control versus ADHD model". Brain, Behavior, and Immunity, 68: 169-182. https://doi.org/10.1016/j.bbi.2017.10.016
Leitão, Ricardo Alexandre; Ventura, Fabiana; Fontes-Ribeiro, Carlos A; Silva, Ana Paula. 2018. Endothelial cell dysfunction induced by methamphetamine: role of neuropeptide Y system. Em 11th FENS Forum of Neuroscience.
Vanessa Coelho-Santos; Filipa L Cardoso; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Silva. 2018. Early developmental long-lasting exposure to methylphenidate: New insights into attention-deficit/hyperactivity disorder. Em ISDN 2018: 22nd Biennial Meeting of theInternational Society for Developmental Neuroscience.
Fabiana Ventura; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Silva. 2018. Behavioural alterations and blood-brain barrier dysfunction triggered by methamphetamine: What is the role of neuropeptide Y?. Em 9th Annual International Medical Students (AIMS)Meeting..
Vanessa Coelho-Santos; Filipa L Cardoso; Ana Magalhães; Margarida Ferreira-Teixeira; Ricardo Alexandre Leitão; Célia Gomes; Manuel Rito; et al. 2018. Neurogliovascular alterations triggered by early developmental chronic consumption of methylphenidate. Em Neural Development – EMBO Workshop.
Joana Gonçalves; Inês R Violante; José Sereno; Ricardo Alexandre Leitão; Ana Paula Silva; Ying Cai; Antero Abrunhosa; Alcino J Silva; Miguel Castelo-Branco. 2018. "Glutamate/GABA- glutamine cycle imbalance in a mouse model of autism spectrum disorder: relationship to glial reactivity". Trabalho apresentado em Neuroscience 2018, San Diego, Estados Unidos.
2018. Implementation of a model of primary cultures of rodent (rat and mice) brain astrocytes .
2018. Methodologies to quantify cell morphology alterations. https://doi.org/10.1016j.bbi.2017.10.016
2018. Animal model of traumatic brain injury (TBI; closed head weight-drop model). Mimics the outcomes observed in blunts, falls or car accidents (represents 75% of all TBI clinical admissions). This model has also been used in a PhD thesis (Faculty of Medicine, Univ of Coimbra). .
Gonçalves, Joana; Violante, Inês R.; Sereno, José Vitor Oliveira; Leitão, Ricardo Alexandre; Cai, Y; Abrunhosa, Antero; Silva, AP; Silva, AJ; Castelo-Branco, Miguel. 2018. "The excitation/inhibition enigma in a mouse model of the autism spectrum disorder: evidence for distinct phenotypes of hippocampus and prefrontal cortex". Trabalho apresentado em 11th FENS - Forum of European Neuroscience, Berlin, Alemanha.
Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo Alexandre; Gomes, Célia; Rito, Manuel; et al. 2018. "Neurovascular unit alterations triggered by methylphenidate: outcome on memory performance.". Trabalho apresentado em 11th FENS 2018 - Forum of European Neuroscience, Berlim, Alemanha, F097.
Leitão, Ricardo Alexandre; Sereno, José; Castelhano, João Miguel; Gonçalves, Sónia Isabel; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Castelo-Branco, Miguel; Silva, Ana Paula. 2017. "Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior". Molecular Neurobiology, 55 (3): 2056-2069. https://doi.org/10.1007/s12035-017-0439-0
Gonçalves, Joana; Leitão, Ricardo A.; Higuera-Matas, Alejandro; Assis, María Amparo; Coria, Santiago M.; Fontes-Ribeiro, Carlos; Ambrosio, Emilio; Silva, Ana Paula. 2017. "Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown". Brain, Behavior, and Immunity, 62: 306-317. https://doi.org/10.1016/j.bbi.2017.02.017
Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel. 2017. "Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes". Molecular Autism, 8 (1). https://doi.org/10.1186/s13229-017-0166-4
Leitão, Ricardo Alexandre Gomes. 2017. "Role of aquaporin-4 in methamphetamine-induced blood-brain barrier dysfunction and cerebral edema formation". Doutoramento. http://hdl.handle.net/10316/40920
Leitão, Ricardo Alexandre. 2017. Neurogliovascular unit dysfunction induced by methamphetamine: protective role of parthenolide. Em XIII European Meeting on Glial Cells in Health and Disease.
Leitão, Ricardo A.; Cardoso, Filipa L.; Coelho-Santos, V.; Fontes-Ribeiro, Carlos A.; Silva, Ana P.. 2017. "Neurogliovascular unit dysfunction induced by methamphetamine: protective role of parthenolide.". Trabalho apresentado em XIII European Meeting on Glial Cells in Health and Disease, Edimburgo, Reino Unido, 65 (S1).
Vanessa Coelho-Santos; Cardoso, Filipa Lourenço; Ricardo Alexandre Leitão; Ana Magalhães; Margarida Ferreira-Teixeira; Célia Gomes; Manuel Rito; et al. 2017. Neurogliovascular alterations induced by chronic treatment of methylphenidate: repercussions on memory function. Em Reactive gliosis - from mechanobiology and signal transduction to molecular targets and disease pathogenesis.
Vanessa Coelho-Santos; Cardoso, Filipa Lourenço; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD. 2017. Effects of early developmental chronic exposure to methylphenidate on both brain´s immune privilege and anxiety-like behavior: Control vs ADHD rats. Em XV Portuguese Society for Neuroscience, Braga, Portugal.
Vanessa Coelho-Santos; Filipa L Cardoso; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Silva. 2017. Brain immune response triggered byearly developmental chronic consumption of methylphenidate: control vs attention-deficit/hyperactivity disorder rat model. Em XXVI AINI Congress and 16th ESNI Course.
Vanessa Coelho-Santos; Ricardo Alexandre Leitão; Ana Magalhães; Margarida Ferreira-Teixeira; Célia Gomes; Manuel Rito; Marcos Barbosa; Carlos A Fontes-Ribeiro; Ana Paula Silva. 2017. Neurogliovascular alterations induced by chronic treatment of methylphenidate: repercussions on memory function. Em Reactive gliosis - from mechanobiology and signaltransduction to molecular targets and disease pathogenesis.
Ana Paula Silva; Vanessa Coelho-Santos; Filipa L Cardoso; Ana Magalhães; Ricardo Alexandre Leitão; Manuel Rito; Marcos Barbosa; Carlos A Fontes-Ribeiro. 2017. "Unravelling the impact of methylphenidate on neurogliovascular function: implications for memory performance". Trabalho apresentado em XIIIEuropean Meeting on Glial Cells in Health and Disease, Edinburgh, Reino Unido, 65 (S1).
Coelho-Santos, Vanessa; Socodato, Renato; Portugal, Camila; Leitão, Ricardo A; Rito, Manuel; Barbosa, Marcos; Couraud, Pierre-Olivier; et al. 2016. "Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells". Cellular and Molecular Life Sciences, 73 (24): 4701-4716. https://doi.org/10.1007/s00018-016-2301-3
Leitão, Ricardo Alexandre; Coelho-Santos, Vanessa; Silva, Ana Paula. 2016. "Methamphetamine and the Blood–Brain Barrier". Em Neuropathology of Drug Addictions and Substance Misuse, 155-168. United Kingdom: Elsevier. https://doi.org/10.1016/B978-0-12-800212-4.00015-7
Leitão, Ricardo Alexandre; Cardoso, Filipa Lourenço; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2016. Protective effect of parthenolide in methamphetamine-induced neuroinflammation and neurovascular dysfunction.. Em 10th FENS Forum of Neuroscience.
Coelho-Santos, V.; Leitão, R.A.; Cardoso, F.L.; Palmela, I.; Rito, M.; Barbosa, M.; Brito, M.A.; Fontes-Ribeiro, C.A.; Silva, A.P.. 2016. "Erratum: The TNF-a/NF-¿B signaling pathway has a key role in methamphetamine'induced blood'brain barrier dysfunction (Journal of Cerebral Blood Flow and Metabolism (2015) 35 (1260-1271))". Journal of Cerebral Blood Flow and Metabolism, 36 (2). https://doi.org/10.1177/0271678X15619790
Vanessa Coelho-Santos; Cardoso, Filipa Lourenço; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD. 2016. Impact of methylphenidate chronic treatment in brain immune surveillance and neuroinflammation: control vs hyperactive rats. Em Society for Neuroscience.
Vanessa Coelho-Santos; Cardoso, Filipa Lourenço; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD. 2016. O impacto da administração crónica de metilfenidato na barreira hematoencefálica num modelo animal de hiperatividade . Em 6º Simpósio de PHDA.
Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. 2016. "Central effects of chronic methylphenidate treatment in control and hyperactive rats: neuroinflammation and blood-brain barrier.". Trabalho apresentado em Neuroscience 2016, San Diego, Estados Unidos, 516.07.
Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. 2016. "Blood-brain barrier dysfunction induced by chronic methylphenidate treatment: control vs. hyperactive rats". Trabalho apresentado em 41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kusadasi, Turquia, 283 (1), 09.02.2-001-265.
Silva, Ana Paula; Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.. 2016. "Methylphenidate promotes brain endotelial hyperpermeability: in vitro and animal studies. ". Trabalho apresentado em 10th FENS 2016 - Forum of European Neuroscience, Copenhagen, Dinamarca, C145.
Coelho-Santos, Vanessa; Leitão, Ricardo A; Cardoso, Filipa L; Palmela, Inês; Rito, Manuel; Barbosa, Marcos; Brito, Maria A; Fontes-Ribeiro, Carlos A; Silva, Ana P. 2015. "The TNF-a/Nf-kB Signaling Pathway has a Key Role in Methamphetamine–Induced Blood–Brain Barrier Dysfunction". Journal of Cerebral Blood Flow & Metabolism, 35 (8): 1260-1271. https://doi.org/10.1038/jcbfm.2015.59
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2015. Aquaporin 4 is involved in brain edema and blood-brain barrier disruption induced by methamphetamine. Em XII European Meeting on Glial Cell Function in Health and Disease.
Leitão, Ricardo Alexandre; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2015. Methamphetamine-induced blood-brain barrier disruption and brain edema: The role of water channel aquaporin-4. . Em XIV Meeting of Portuguese Society of Neuroscience.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2015. Role of aquaporin 4 in methamphetamine-induced blood-brain barrier dysfunction and brain edema. . Em IV In4Med.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2015. "Aquaporin 4 is involved in brain edema and blood-brain barrier disruption induced by methamphetamine.". Trabalho apresentado em XII European Meeting on Glial Cell Function in Health and Disease, Bilbao, Spain, 63 (S1), E408-E409.
Leitão, Ricardo Alexandre; Silva, Ana Paula. 2015. "Psychostimulants and brain edema ". Research & Networks in Health, 1 (1). https://journals.ipleiria.pt/index.php/rnhealth/article/view/60
Vanessa Coelho-Santos; Cardoso, Filipa Lourenço; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro; Ana Paula Pereira da Silva Martins, PhD. 2015. Effects of chronic exposure to methylphenidate on behavior and blood-brain barrier function: control vs hyperactive rats . Em VII Annual Meeting of IBILI.
Vanessa Coelho-Santos; Renato Socodato; Camila C. Portugal; Ricardo Alexandre Leitão; Manuel Rito; Marcos Barbosa; Cardoso, Filipa Lourenço; et al. 2015. Methylphenidate activates Src pathway leading to caveolae-mediated transcytosis in human brain endothelial cells. Em XIV Portuguese Society for Neurosciences.
2015. Primary cultures of human brain endothelial cells. https://doi.org/10.1038jcbfm.2015.59
Coelho-Santos, Vanessa; Socodato, Renato; Portugal, Camila; Leitão, Ricardo Alexandre; Rito, Manuel; Barbosa, Marcos; Couraud, Pierre-Olivier; et al. 2015. Unmasking the underlying mechanisms of methylphenidate effects on human brain endothelial cells.. Em In4Med, Medical and Scientific Meeting (Coimbra, Portugal).
Gonçalves, Joana; Leitão, Ricardo Alexandre; Ambrosio, Emilio; Silva, Ana Paula. 2015. "Methamphetamine self-administration induces blood-brain barrier dysfunction in the rat hippocampus. ". Trabalho apresentado em 9th IBRO World Congress of Neuroscience, Rio de Janeiro, Brasil, (B357).
Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo Alexandre; Cai, Yin; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel. 2015. Regional difference in susceptibility to modulation of excitation/inhibition balance and glial function in mouse model of neurofibromatosis type 1.. Em IBILI Meeting 2015.
Leitão, Ricardo Alexandre; Gonçalves, Joana; Assis, María Amparo; Coria, Santiago M.; Ambrosio, Emilio; Silva, Ana Paula. 2015. Blood-brain barrier dysfunction and neuroinflammation triggered by chronic methamphetamine self-admnistration in rats.. Em IBILI Meeting 2015.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2014. Role of aquaporin-4 in brain edema and blood-brain barrier breakdown induced by methamphetamine. . Em XVIII Congress of the Portuguese Biochemical Society.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2014. Methamphetamine-induced blood-brain barrier dysfunction: role of Aquaporin 4. . Em VI Annual Meeting of IBILI.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2014. Methamphetamine-induced blood-brain barrier dysfunction: role of Aquaporin 4. . Em 17th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2014. Role of brain edema in methamphetamine-induced blood-brain barrier dysfunction. . Em Astrocytes in Health and Neurodegenerative Disease..
Vanessa Coelho-Santos; Ricardo Alexandre Leitão; Cardoso, Filipa Lourenço; Fontes-Ribeiro, Carlos A.; Maria Alexandra Brito; Ana Paula Pereira da Silva Martins, PhD. 2014. "Role of nuclear factor-kappa B signalling in methamphetamine-induced blood-brain barrier dysfunction". Trabalho apresentado em 27th ECNP Congress, Berlim, Alemanha, 24 (Suppl 2).
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. 2014. Role of aquaporin-4 in methamphetamine-induced brain edema and blood-brain barrier dysfunction.. Em Astrocytes in Health and Neurodegenerative Disease. A joint Biochemical Society / British Neuroscience Association Focused Meeting (London, UK).
Coelho-Santos, Vanessa; Leitão, R.A.; Cardoso, F.L.; Palmela, I.; Rito, M.; Barbosa, M.; Brito, M.A.; Fontes-Ribeiro, C.; Silva, A.P.. 2014. "P.6.c.001 Role of nuclear factor-kappa B signalling in methamphetamine-induced blood–brain barrier dysfunction". European Neuropsychopharmacology, 24. https://doi.org/10.1016/s0924-977x(14)71087-9
Leitão, Ricardo Alexandre; Coelho-Santos, Vanessa; Cardoso, Filipa Lourenço; Fontes-Ribeiro, Carlos; Brito, Maria A; Silva, Ana Paula. 2013. Disfunção da barreira hematoencefálica induzida por metanfetamina (Methamphetamine-induced blood-brain barrier dysfunction) . Em Congresso Nacional de Adictologia - Saúde, Neurociências e Adições.
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2013. Methamphetamine induces alterations in brain aquaporin 4 expression. . Em 4th PF2MUC Symposium - Personalized Medicine: myth or reality?.
Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Cardoso, Filipa Lourenço; Fontes-Ribeiro, Carlos; Brito, Maria A; Silva, Ana Paula. 2013. The role of TNF-a in METH-induced barrier dysfunction.. Em XIII Meeting of the Portuguese Society for Neuroscience.
Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Cardoso, Filipa Lourenço; Fontes-Ribeiro, Carlos; Brito, Maria A; Silva, Ana Paula. 2013. Impact of methamphetamine on the crosstalk between brain endothelial cells and astrocytes: implications for barrier function. . Em Beating the Blood-Brain & Other Blood Barriers.
Vanessa Coelho-Santos; Ricardo Alexandre Leitão; Cardoso, Filipa Lourenço; Carlos A Fontes-Ribeiro; Maria Alexandra Brito; Ana Paula Pereira da Silva Martins, PhD. 2013. Impact of methamphetamine on the crosstalk between brain endothelial cells and astrocytes: implications for barrier function. Em Beating the blood brain & other blood barriers.
Vanessa Coelho-Santos; Ricardo Alexandre Leitão; Cardoso, Filipa Lourenço; Carlos A Fontes-Ribeiro; Maria Alexandra Brito; Ana Paula Pereira da Silva Martins, PhD. 2013. The role of TNF-a in METH-induced barrier dysfunction. Em 13th Meeting of the Portuguese Society for Neurosciences.
Ana Paula Pereira da Silva Martins, PhD; Vanessa Coelho-Santos; Ricardo Alexandre Leitão; Carlos A Fontes-Ribeiro. 2013. Methamphetamine-induced blood-brain barrier dysfunction: role of TNF-a. Em FENS Featured Regional Meeting.
Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Cardoso, Filipa L.; Fontes-Ribeiro, Carlos A.; Brito, Maria Alexandra; Silva, Ana Paula. 2013. The role of TNF-alpha in METH-induced barrier dysfunction.. Em XIII Portuguese Society for Neuroscience (Luso, Portugal).
Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. 2012. Methamphetamine induces alterations in brain aquaporin 4 expression. . Em IV Annual Meeting of IBILI.
Leitão, Ricardo Alexandre Gomes. 2012. "Impact of methamphetamine on astrocytes and endothelial cells : role of aquaporin-4". Mestrado. http://hdl.handle.net/10316/26093
Carlos A Fontes-Ribeiro; Vitor Pinheiro; Sofia Baptista; Joana Gonçalves; Ricardo Alexandre Leitão; Ana Paula Pereira da Silva Martins, PhD. 2012. Acute physical exercise and blood-brain barrier permeability. Em 17th Annual ECSS Congress.
Carlos A Fontes-Ribeiro; Vitor Pinheiro; Sofia Baptista; Joana Gonçalves; Ricardo Alexandre Leitão; Ana Paula Silva. 2012. Acute physical exercise and blood-brain barrier permeability.. Em 17th Annual ECSS Congress.