Silhueta de pessoa indiferenciada

Ana Teresa Luís Lopes Maia

Professor auxiliar
Centro de Investigação em Tecnologias e Serviços de Saúde
Subsistema
Docentes Universitário
Unidade ID
Centro de Investigação em Tecnologias e Serviços de Saúde
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Ana Teresa Luís Lopes Maia.

Atividades

Atividades
2015/12/21 - 2021/12/09. Orientação. UNVEILING THE ROLE OF CIS-REGULATORY VARIATION IN BREAST CANCER AETIOLOGY.Outras Ciências Médicas (Doutoramento). Orientador.
2019/01/09 - 2021/04/21. Orientação. Alternative splicing-mediated cis-regulation in breast cancer risk.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado) (Mestrado). Orientador.
2019 - 2019. Orientação. INFLUENCE OF SOMATIC MUTANT ALLELIC IMBALANCE IN BREAST CANCER CLINICAL CHARACTERISTICS.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2019 - 2019. Orientação. IDENTIFYING NOVEL GENES ASSOCIATED WITH BREAST CANCER SUSCEPTIBILITY USING DIFFERENTIAL ALLELIC EXPRESSION RATIOS.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2018 - 2018. Orientação. The role of miRNA-mediated cis-regulation in breast cancer susceptibility.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2018 - 2018. Orientação. Study of the impact of IL7R gain-of-function mutation on in vivo leukemogenesis.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2017 - 2017. Orientação. Functional analysis of genetic variants associated with risk for breast cancer: 12q24, a candidate risk locus.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2017 - 2017. Orientação. Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2012/01/12 - 2017/05/19. Orientação. MOLECULAR AND FUNCTIONAL ANALYSIS OF DAND5 IN HUMAN CONGENITAL HEART DISEASE (CHD).Ciências da Saúde (Doutoramento). Coorientador.
2016 - 2016. Orientação. Epigenetics and alternative splicing.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2016 - 2016. Orientação. Role of chemerin and its receptors in mouse models of tumorigenesis.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2015 - 2015. Orientação. Constitutive OGG1 variant together with BRCA mutations display accelerated telomere shortening.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2015 - 2015. Orientação. Functional characterisation of putative Cis-Regulatory Risk Loci for breast cancer.Qualidade em Análises (Mestrado). Orientador.
2014 - 2014. Orientação. STUDY OF INFLUENCE OF REGULATORY POLYMORPHISMS OF EXPRESSION IN DEVELOPMENT OF BREAST CANCER.Ciências Biomédicas (Mestrado). Orientador.
2014 - 2014. Orientação. Identification of regulatory polymorphisms associated with breast cancer risk.Ciências Biomédicas (Mestrado). Orientador.

Projetos

Projetos
2021/12 - 2023/12. Unraveling the contribution of mitotic failure in rare syndromes with microcephaly susceptibility. Investigador. Universidade do Algarve.
2022/01 - 2024/10. Lobular Breast Cancer: Discovery Science, Translational Goals, Clinical Impact (LOBSTERPOT).
2019/03/28 - 2022/03/27. Inovação de GWAS em cancro da mama através da integração de genómica funcional, 9471 - RIDTI. Investigador. Universidade do Algarve; Instituto de Medicina Molecular João Lobo Antunes.
2018/07/01 - 2021/06/30. Descodificação da evolução do cancro da mama através de assinaturas de expressão diferencial do alelo mutado, 9471 - RIDTI. Investigador responsável. Universidade do Algarve.
2012/06/01 - 2017/03/17. Genetic Control of Gene Expression in Cancer Risk, SEVENTH FRAMEWORK PROGRAMME (FP7). Investigador responsável. Universidade do Algarve Centro de Investigação em Biomedicina.
2013/07/01 - 2015/12/31. Cis-regulação de mutações somáticas nos cancros da mama e do ovário, 3599-PPCDT. Investigador responsável. Instituto de Biotecnologia e Bioengenharia; Universidade do Algarve.
2009 - 2010. Differential Allelic Expression Analysis of Susceptibility Loci in Breast Cancer. Bolseiro de Investigação.
2008 - 2009. Differential Allelic Expression Analysis of Susceptibility Loci in Breast Cancer. Bolseiro de Investigação.

Produções

Correia, Lizelle; Magno, Ramiro; Xavier, Joana; Maia, Ana-Teresa. Autor correspondente: Maia, Ana-Teresa. 2022. "Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant". npj Breast Cancer. https://doi.org/10.1101/2021.03.05.434137
Joana M. Xavier; Magno, Ramiro; Maia, Ana-Teresa. Autor correspondente: Maia, Ana-Teresa. 2022. "Mapping of cis-regulatory variants by differential allelic expression analysis identifies candidate risk variants and target genes of 27 breast cancer risk loci". medRxiv. MEDRXIV/2022/271889
2021. "Methods of analysis of polymorphisms associated with allelic expression of PIK3CA in cancer and uses thereof". Protegido.
2021. "Methods of Analysis of polymorphisms associated with cancer and uses thereof". Protegido.
Marta Liber; Guilhermina Isabel dos Santos Duarte; Maia, Ana-Teresa; Hugo Rafael Cardoso Oliveira. 2021. "The history of lentil (Lens culinaris subsp. culinaris) domestication and spread as revealed by Genotyping-by-Sequencing of wild and landrace accessions". Frontiers in Plant Science, 12. https://doi.org/10.3389/fpls.2021.628439
Ramiro Magno; Isabel Duarte; Ana-Teresa Maia. 2021. "quincunx: an R package to query, download and wrangle PGS Catalog data". Bioinformatics. https://doi.org/10.1093/bioinformatics/btab522
Filipa Esteves; Joana M. Xavier; Ana-Teresa Maia. Autor correspondente: Ana-Teresa Maia. 2021. "Germline Allelic Expression of Genes at 17q22 Locus Associates with Risk of Breast Cancer". deposited at MEDRXIV/2021/267625, Minor Revisions at European Journal of Cancer. https://doi.org/10.1101/2021.12.10.21267625
Ana Jacinta-Fernandes; Joana M. Xavier; Ramiro Magno; Joel G. Lage; Ana-Teresa Maia. 2020. "Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk". npj Genomic Medicine. https://doi.org/10.1038/s41525-019-0112-9
Duarte, André; Magno, Ramiro; Paulo José Martel (AD16-8C2A-26CE); Maia, Ana-Teresa. Autor correspondente: Maia, Ana-Teresa. 2020. Alternative splicing in breast cancer risk. https://doi.org/10.5281/ZENODO.3776118
Juliana Machado; Ramiro Magno; Joana M Xavier; Ana-Teresa Maia. 2019. Alternative splicing regulation by GWAS risk loci for breast cancer. https://doi.org/10.1101/766394
Magno, Ramiro; Maia, Ana-Teresa. 2019. "gwasrapidd: an R package to query, download and wrangle GWAS catalog data". Bioinformatics. https://doi.org/10.1093/bioinformatics/btz605
Matias, A.T.; Jacinta-Fernandes, A.; Magno, R.; Xavier, J.; Cabral, M.G.; Jacinto, A.; Maia, A.T.; Braga, S.. 2018. "Differential molecular signature in patients from African origin with triple-negative breast cancer". Annals of Oncology, 29. https://doi.org/10.1093/annonc/mdy272.290
Maia, A.-T.; Sammut, S.-J.; Jacinta-Fernandes, A.; Chin, S.-F.. 2017. "Big data in cancer genomics". Current Opinion in Systems Biology, 4: 78-84. https://doi.org/10.1016/j.coisb.2017.07.007
Faleiro, I.; Leão, R.; Binnie, A.; de Mello, R.A.; Maia, A.-T.; Castelo-Branco, P.. 2017. "Epigenetic therapy in urologic cancers: An update on clinical trials". Oncotarget, 8 (7): 12484-12500. https://doi.org/10.18632/oncotarget.14226
Xavier, Joana; Russell, Roslin; Almeida, Bernardo P.; Rosli, Nordiana; Rocha, Catia; Samarajiwa, Shamith; Chin, Suet-Feung; et al. 2016. "Abstract A31: Integrative differential allelic expression analysis efficiently reveals the biology underlying risk to breast cancer". Molecular Cancer Research, 14 (2 Suppleme): A31-A31. https://doi.org/10.1158/1557-3125.advbc15-a31
Xavier, J.; Almeida, B.; Sun, C.; Silva, J.; Marreiros, A.; Eldridge, M.; Bernards, R.; et al. 2016. "PIK3CA mutant allele differential expression (MADE) associates with breast cancer clinical features". European Journal of Cancer, 61. https://doi.org/10.1016/s0959-8049(16)61723-9
Peterlongo, P.; Chang-Claude, J.; Moysich, K.B.; Rudolph, A.; Schmutzler, R.K.; Simard, J.; Soucy, P.; et al. 2015. "Candidate genetic modifiers for breast and ovarian cancer risk inBRCA1andBRCA2 mutation carriers". Cancer Epidemiology Biomarkers and Prevention, 24 (1): 308-316. https://doi.org/10.1158/1055-9965.EPI-14-0532
Vollan, H.K.M.; Rueda, O.M.; Chin, S.-F.; Curtis, C.; Turashvili, G.; Shah, S.; Lingjærde, O.C.; et al. 2015. "A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer". Molecular Oncology, 9 (1): 115-127. https://doi.org/10.1016/j.molonc.2014.07.019
Jones, J.O.; Chin, S.-F.; Wong-Taylor, L.-A.; Leaford, D.; Ponder, B.A.J.; Caldas, C.; Maia, A.-T.. 2013. "TOX3 Mutations in Breast Cancer". PLoS ONE, 8 (9). https://doi.org/10.1371/journal.pone.0074102
French, J.D.; Ghoussaini, M.; Edwards, S.L.; Meyer, K.B.; Michailidou, K.; Ahmed, S.; Khan, S.; et al. 2013. "Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers". American Journal of Human Genetics, 92 (4): 489-503. https://doi.org/10.1016/j.ajhg.2013.01.002
Curtis, C.; Shah, S.P.; Chin, S.-F.; Turashvili, G.; Rueda, O.M.; Dunning, M.J.; Speed, D.; et al. 2012. "The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups". Nature, 486 (7403): 346-352. https://doi.org/10.1038/nature10983
Maia, A.-T.; Antoniou, A.C.; O'Reilly, M.; Samarajiwa, S.; Dunning, M.; Kartsonaki, C.; Chin, S.-F.; et al. 2012. "Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers". Breast Cancer Research, 14 (2). https://doi.org/10.1186/bcr3169
Liu, R.; Maia, A.; Russell, R.; Caldas, C.; Ponder, B.A.; Ritchie, M.E.. 2012. "Allele-specific expression analysis methods for high-density SNP microarray data". Bioinformatics, 28 (8): 1102-1108. https://doi.org/10.1093/bioinformatics/bts089
Meyer, K.B.; Maia, A.-T.; O'Reilly, M.; Ghoussaini, M.; Prathalingam, R.; Porter-Gill, P.; Ambs, S.; et al. 2011. "A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression". PLoS Genetics, 7 (7). https://doi.org/10.1371/journal.pgen.1002165
Udler, M.S.; Ahmed, S.; Healey, C.S.; Meyer, K.; Struewing, J.; Maranian, M.; Kwon, E.M.; et al. 2010. "Fine scale mapping of the breast cancer 16q12 locus". Human Molecular Genetics, 19 (12): 2507-2515. https://doi.org/10.1093/hmg/ddq122
Azzato, E.M.; Lee, A.J.X.; Teschendorff, A.; Ponder, B.A.J.; Pharoah, P.; Caldas, C.; Maia, A.T.. 2010. "Common germ-line polymorphism of C1QA and breast cancer survival". British Journal of Cancer, 102 (8): 1294-1299. https://doi.org/10.1038/sj.bjc.6605625
Alves, M.; Carreira, I.; Liberato, P.; Ramos, S.; Mafra, M.; Inverno, A.S.; Maia, A.T.; et al. 2010. "Identification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinoma". Oncology Reports, 23 (2): 519-522. https://doi.org/10.3892/or-00000664
Maia, A.; Spiteri, I.; Lee, A.J.X.; O'Reilly, M.; Jones, L.; Caldas, C.; Ponder, B.A.J.. 2009. "Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast". Breast Cancer Research, 11 (6). https://doi.org/10.1186/bcr2458
Dunning, A.M.; Healey, C.S.; Baynes, C.; Maia, A.-T.; Scollen, S.; Vega, A.; Rodríguez, R.; et al. 2009. "Association of ESR1 gene tagging SNPs with breast cancer risk". Human Molecular Genetics, 18 (6): 1131-1139. https://doi.org/10.1093/hmg/ddn429
Barber, M.; Murrell, A.; Ito, Y.; Maia, A.-T.; Hyland, S.; Oliveira, C.; Save, V.; et al. 2008. "Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer". Journal of Pathology, 216 (3): 295-306. https://doi.org/10.1002/path.2426
Ito, Y.; Koessler, T.; Ibrahim, A.E.K.; Rai, S.; Vowler, S.L.; Abu-amero, S.; Silva, A.-L.; et al. 2008. "Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer". Human Molecular Genetics, 17 (17): 2633-2643. https://doi.org/10.1093/hmg/ddn163
Meyer, K.B.; Maia, A.-T.; O'Reilly, M.; Teschendorff, A.E.; Chin, S.-F.; Caldas, C.; Ponder, B.A.J.. 2008. "Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer". PLoS Biology, 6 (5): 1098-1103. https://doi.org/10.1371/journal.pbio.0060108
Udler, M.; Maia, A.-T.; Cebrian, A.; Brown, C.; Greenberg, D.; Shah, M.; Caldas, C.; et al. 2007. "Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer". Journal of Clinical Oncology, 25 (21): 3015-3023. https://doi.org/10.1200/JCO.2006.10.0099
Bundy, J.G.; Iyer, N.G.; Gentile, M.S.; Hu, D.-E.; Kettunen, M.; Maia, A.-T.; Thorne, N.P.; et al. 2006. "Metabolic consequences of p300 gene deletion in human colon cancer cells". Cancer Research, 66 (15): 7606-7614. https://doi.org/10.1158/0008-5472.CAN-05-2999
Maia, A.T.; Tussiwand, R.; Cazzaniga, G.; Rebulla, P.; Colman, S.; Biondi, A.; Greaves, M.. 2004. "Identification of Preleukemic Precursors of Hyperdiploid Acute Lymphoblastic Leukemia in Cord Blood". Genes Chromosomes and Cancer, 40 (1): 38-43. https://doi.org/10.1002/gcc.20010
Maia, A.T.; Koechling, J.; Corbett, R.; Metzler, M.; Wiemels, J.L.; Greaves, M.. 2004. "Protracted Postnatal Natural Histories in Childhood Leukemia". Genes Chromosomes and Cancer, 39 (4): 335-340. https://doi.org/10.1002/gcc.20003
Zuna, J.; Muzikova, K.; Ford, A.M.; Maia, A.T.; Krejci, O.; Tousovska, K.; Oravkinova, I.; Greaves, M.; Trka, J.. 2003. "Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets". Leukemia and Lymphoma, 44 (12): 2099-2102. https://doi.org/10.1080/1042819031000123393
Maia, A.T.; van der Velden, V.H.J.; Harrison, C.J.; Szczepanski, T.; Williams, M.D.; Griffiths, M.J.; van Dongen, J.J.M.; Greaves, M.F.. 2003. "Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins". Leukemia, 17 (11): 2202-2206. https://doi.org/10.1038/sj.leu.2403101
Greaves, M.F.; Maia, A.T.; Wiemels, J.L.; Ford, A.M.. 2003. "Leukemia in twins: Lessons in natural history". Blood, 102 (7): 2321-2333. https://doi.org/10.1182/blood-2002-12-3817
Maia, Ana-Teresa. 2003. "Molecular genetics and natural history of childhood leukaemia". Doutoramento.
Wiemels, J.L.; Xiao, Z.; Buffler, P.A.; Maia, A.T.; Ma, X.; Dicks, B.M.; Smith, M.T.; et al. 2002. "In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia". Blood, 99 (10): 3801-3805. https://doi.org/10.1182/blood.V99.10.3801
Maia, A.T.; Ford, A.M.; Reza Jalali, G.; Harrison, C.J.; Malcolm Taylor, G.; Eden, O.B.; Greaves, M.F.. 2001. "Molecular tracking of leukemogenesis in a triplet pregnancy". Blood, 98 (2): 478-482. https://doi.org/10.1182/blood.V98.2.478
 

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