Silhueta de pessoa indiferenciada

Ana Teresa Luís Lopes Maia

Professor auxiliar
Centro de Investigação em Tecnologias e Serviços de Saúde
Subsistema
Docentes Universitário
Unidade ID
Centro de Investigação em Tecnologias e Serviços de Saúde
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Ana Teresa Luís Lopes Maia.

Atividades

Atividades
2019/01/09 - 2021/04/21. Orientação. Alternative splicing-mediated cis-regulation in breast cancer risk.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado) (Mestrado). Orientador.
2019 - 2019. Orientação. INFLUENCE OF SOMATIC MUTANT ALLELIC IMBALANCE IN BREAST CANCER CLINICAL CHARACTERISTICS.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2019 - 2019. Orientação. IDENTIFYING NOVEL GENES ASSOCIATED WITH BREAST CANCER SUSCEPTIBILITY USING DIFFERENTIAL ALLELIC EXPRESSION RATIOS.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2018 - 2018. Orientação. The role of miRNA-mediated cis-regulation in breast cancer susceptibility.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2018 - 2018. Orientação. Study of the impact of IL7R gain-of-function mutation on in vivo leukemogenesis.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2017 - 2017. Orientação. Functional analysis of genetic variants associated with risk for breast cancer: 12q24, a candidate risk locus.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2017 - 2017. Orientação. Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2016 - 2016. Orientação. Epigenetics and alternative splicing.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2016 - 2016. Orientação. Role of chemerin and its receptors in mouse models of tumorigenesis.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2015 - 2015. Orientação. Constitutive OGG1 variant together with BRCA mutations display accelerated telomere shortening.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2015 - 2015. Orientação. Functional characterisation of putative Cis-Regulatory Risk Loci for breast cancer.Qualidade em Análises (Mestrado). Orientador.
2014 - 2014. Orientação. STUDY OF INFLUENCE OF REGULATORY POLYMORPHISMS OF EXPRESSION IN DEVELOPMENT OF BREAST CANCER.Ciências Biomédicas (Mestrado). Orientador.
2014 - 2014. Orientação. Identification of regulatory polymorphisms associated with breast cancer risk.Ciências Biomédicas (Mestrado). Orientador.
2012 - 2012. Orientação. MOLECULAR AND FUNCTIONAL ANALYSIS OF DAND5 IN HUMAN CONGENITAL HEART DISEASE (CHD).Ciências Biomédicas (Doutoramento). Coorientador.

Projetos

Projetos
2009 - 2010. Differential Allelic Expression Analysis of Susceptibility Loci in Breast Cancer. Investigador. Breast Cancer Research Foundation.
2008 - 2009. Differential Allelic Expression Analysis of Susceptibility Loci in Breast Cancer. Investigador. Breast Cancer Research Foundation.
2019/03/28 - 2022/03/27. Inovação de GWAS em cancro da mama através da integração de genómica funcional, 9471 - RIDTI. Investigador. Universidade do Algarve; Instituto de Medicina Molecular João Lobo Antunes.
2018/07/01 - 2021/06/30. Descodificação da evolução do cancro da mama através de assinaturas de expressão diferencial do alelo mutado, 9471 - RIDTI. Investigador responsável. Universidade do Algarve.
2015 - 2017. À descoberta da importância da cis-regulação na susceptibilidade do cancro da mama, 1st Maratona da Saúde Award. Investigador responsável. Universidade do Algarve Centro de Investigação em Biomedicina.
2012/06/01 - 2017/03/17. Genetic Control of Gene Expression in Cancer Risk, SEVENTH FRAMEWORK PROGRAMME (FP7). Investigador responsável. Universidade do Algarve Centro de Investigação em Biomedicina.
2013/07/01 - 2015/12/31. Cis-regulação de mutações somáticas nos cancros da mama e do ovário, 3599-PPCDT. Investigador responsável. Instituto de Biotecnologia e Bioengenharia; Universidade do Algarve.

Produções

Ramiro Magno; Isabel Duarte; Ana -Teresa Maia. 2021. "quincunx: an R package to query, download and wrangle PGS Catalog data". https://doi.org/10.1101/2021.02.19.431997
Correia, Lizelle; Xavier, Joana M; Magno, Ramiro; Maia, Ana-Teresa. Autor correspondente: Maia, Ana-Teresa. 2021. Preferential allelic expression of PIK3CA mutations is frequent in breast cancer and is prognostically significant. https://doi.org/10.1101/2021.03.05.434137
2021. "Methods of analysis of polymorphisms associated with allelic expression of PIK3CA in cancer and uses thereof". Protegido.
Marta Liber (DE12-138F-526B); Guilhermina Isabel dos Santos Duarte (ED15-7F67-7B64); Maia, Ana-Teresa; Hugo Rafael Cardoso Oliveira (4515-38C3-60F6). 2021. "The history of lentil (Lens culinaris subsp. culinaris) domestication and spread as revealed by Genotyping-by-Sequencing of wild and landrace accessions". Frontiers in Plant Science, 12. https://doi.org/10.3389/fpls.2021.628439
Ramiro Magno; Isabel Duarte; Ana-Teresa Maia; Zhiyong Lu. 2021. "quincunx: an R package to query, download and wrangle PGS Catalog data". Bioinformatics. https://doi.org/10.1093/bioinformatics/btab522
Ana Jacinta-Fernandes; Joana M. Xavier; Ramiro Magno; Joel G. Lage; Ana-Teresa Maia. 2020. "Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk". npj Genomic Medicine. https://doi.org/10.1038/s41525-019-0112-9
Maia, Ana-Teresa. 2020. Alternative splicing in breast cancer risk. https://doi.org/10.5281/ZENODO.3776118
Juliana Machado; Ramiro Magno; Joana M Xavier; Ana-Teresa Maia. 2019. Alternative splicing regulation by GWAS risk loci for breast cancer. https://doi.org/10.1101/766394
Magno, Ramiro; Maia, Ana-Teresa. 2019. "gwasrapidd: an R package to query, download and wrangle GWAS catalog data". Bioinformatics. https://doi.org/10.1093/bioinformatics/btz605
Ana Jacinta-Fernandes; Joana M. Xavier; Ramiro Magno; Joel G. Lage; Ana-Teresa Maia. 2019. Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk. https://doi.org/10.1101/777318
2019. "Methods of Analysis of polymorphisms associated with cancer and uses thereof". Protegido.
Matias, A.T.; Jacinta-Fernandes, A.; Magno, R.; Xavier, J.; Cabral, M.G.; Jacinto, A.; Maia, A.T.; Braga, S.. 2018. "Differential molecular signature in patients from African origin with triple-negative breast cancer". Annals of Oncology, 29. https://doi.org/10.1093/annonc/mdy272.290
Maia, A.-T.; Sammut, S.-J.; Jacinta-Fernandes, A.; Chin, S.-F.. 2017. "Big data in cancer genomics". Current Opinion in Systems Biology, 4: 78-84. https://doi.org/10.1016/j.coisb.2017.07.007
Faleiro, I.; Leão, R.; Binnie, A.; de Mello, R.A.; Maia, A.-T.; Castelo-Branco, P.. 2017. "Epigenetic therapy in urologic cancers: An update on clinical trials". Oncotarget, 8 (7): 12484-12500. https://doi.org/10.18632/oncotarget.14226
Xavier, Joana; Russell, Roslin; Almeida, Bernardo P.; Rosli, Nordiana; Rocha, Catia; Samarajiwa, Shamith; Chin, Suet-Feung; et al. 2016. "Abstract A31: Integrative differential allelic expression analysis efficiently reveals the biology underlying risk to breast cancer". Molecular Cancer Research, 14 (2 Suppleme): A31-A31. https://doi.org/10.1158/1557-3125.advbc15-a31
Xavier, J.; Almeida, B.; Sun, C.; Silva, J.; Marreiros, A.; Eldridge, M.; Bernards, R.; et al. 2016. "PIK3CA mutant allele differential expression (MADE) associates with breast cancer clinical features". European Journal of Cancer, 61. https://doi.org/10.1016/s0959-8049(16)61723-9
Peterlongo, P.; Chang-Claude, J.; Moysich, K.B.; Rudolph, A.; Schmutzler, R.K.; Simard, J.; Soucy, P.; et al. 2015. "Candidate genetic modifiers for breast and ovarian cancer risk inBRCA1andBRCA2 mutation carriers". Cancer Epidemiology Biomarkers and Prevention, 24 (1): 308-316. https://doi.org/10.1158/1055-9965.EPI-14-0532
Vollan, H.K.M.; Rueda, O.M.; Chin, S.-F.; Curtis, C.; Turashvili, G.; Shah, S.; Lingjærde, O.C.; et al. 2015. "A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer". Molecular Oncology, 9 (1): 115-127. https://doi.org/10.1016/j.molonc.2014.07.019
Jones, J.O.; Chin, S.-F.; Wong-Taylor, L.-A.; Leaford, D.; Ponder, B.A.J.; Caldas, C.; Maia, A.-T.. 2013. "TOX3 Mutations in Breast Cancer". PLoS ONE, 8 (9). https://doi.org/10.1371/journal.pone.0074102
French, J.D.; Ghoussaini, M.; Edwards, S.L.; Meyer, K.B.; Michailidou, K.; Ahmed, S.; Khan, S.; et al. 2013. "Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers". American Journal of Human Genetics, 92 (4): 489-503. https://doi.org/10.1016/j.ajhg.2013.01.002
Curtis, C.; Shah, S.P.; Chin, S.-F.; Turashvili, G.; Rueda, O.M.; Dunning, M.J.; Speed, D.; et al. 2012. "The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups". Nature, 486 (7403): 346-352. https://doi.org/10.1038/nature10983
Maia, A.-T.; Antoniou, A.C.; O'Reilly, M.; Samarajiwa, S.; Dunning, M.; Kartsonaki, C.; Chin, S.-F.; et al. 2012. "Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers". Breast Cancer Research, 14 (2). https://doi.org/10.1186/bcr3169
Liu, R.; Maia, A.; Russell, R.; Caldas, C.; Ponder, B.A.; Ritchie, M.E.. 2012. "Allele-specific expression analysis methods for high-density SNP microarray data". Bioinformatics, 28 (8): 1102-1108. https://doi.org/10.1093/bioinformatics/bts089
Meyer, K.B.; Maia, A.-T.; O'Reilly, M.; Ghoussaini, M.; Prathalingam, R.; Porter-Gill, P.; Ambs, S.; et al. 2011. "A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression". PLoS Genetics, 7 (7). https://doi.org/10.1371/journal.pgen.1002165
Udler, M.S.; Ahmed, S.; Healey, C.S.; Meyer, K.; Struewing, J.; Maranian, M.; Kwon, E.M.; et al. 2010. "Fine scale mapping of the breast cancer 16q12 locus". Human Molecular Genetics, 19 (12): 2507-2515. https://doi.org/10.1093/hmg/ddq122
Azzato, E.M.; Lee, A.J.X.; Teschendorff, A.; Ponder, B.A.J.; Pharoah, P.; Caldas, C.; Maia, A.T.. 2010. "Common germ-line polymorphism of C1QA and breast cancer survival". British Journal of Cancer, 102 (8): 1294-1299. https://doi.org/10.1038/sj.bjc.6605625
Alves, M.; Carreira, I.; Liberato, P.; Ramos, S.; Mafra, M.; Inverno, A.S.; Maia, A.T.; et al. 2010. "Identification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinoma". Oncology Reports, 23 (2): 519-522. https://doi.org/10.3892/or-00000664
Maia, A.; Spiteri, I.; Lee, A.J.X.; O'Reilly, M.; Jones, L.; Caldas, C.; Ponder, B.A.J.. 2009. "Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast". Breast Cancer Research, 11 (6). https://doi.org/10.1186/bcr2458
Dunning, A.M.; Healey, C.S.; Baynes, C.; Maia, A.-T.; Scollen, S.; Vega, A.; Rodríguez, R.; et al. 2009. "Association of ESR1 gene tagging SNPs with breast cancer risk". Human Molecular Genetics, 18 (6): 1131-1139. https://doi.org/10.1093/hmg/ddn429
Barber, M.; Murrell, A.; Ito, Y.; Maia, A.-T.; Hyland, S.; Oliveira, C.; Save, V.; et al. 2008. "Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer". Journal of Pathology, 216 (3): 295-306. https://doi.org/10.1002/path.2426
Ito, Y.; Koessler, T.; Ibrahim, A.E.K.; Rai, S.; Vowler, S.L.; Abu-amero, S.; Silva, A.-L.; et al. 2008. "Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer". Human Molecular Genetics, 17 (17): 2633-2643. https://doi.org/10.1093/hmg/ddn163
Meyer, K.B.; Maia, A.-T.; O'Reilly, M.; Teschendorff, A.E.; Chin, S.-F.; Caldas, C.; Ponder, B.A.J.. 2008. "Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer". PLoS Biology, 6 (5): 1098-1103. https://doi.org/10.1371/journal.pbio.0060108
Udler, M.; Maia, A.-T.; Cebrian, A.; Brown, C.; Greenberg, D.; Shah, M.; Caldas, C.; et al. 2007. "Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer". Journal of Clinical Oncology, 25 (21): 3015-3023. https://doi.org/10.1200/JCO.2006.10.0099
Bundy, J.G.; Iyer, N.G.; Gentile, M.S.; Hu, D.-E.; Kettunen, M.; Maia, A.-T.; Thorne, N.P.; et al. 2006. "Metabolic consequences of p300 gene deletion in human colon cancer cells". Cancer Research, 66 (15): 7606-7614. https://doi.org/10.1158/0008-5472.CAN-05-2999
Maia, A.T.; Tussiwand, R.; Cazzaniga, G.; Rebulla, P.; Colman, S.; Biondi, A.; Greaves, M.. 2004. "Identification of Preleukemic Precursors of Hyperdiploid Acute Lymphoblastic Leukemia in Cord Blood". Genes Chromosomes and Cancer, 40 (1): 38-43. https://doi.org/10.1002/gcc.20010
Maia, A.T.; Koechling, J.; Corbett, R.; Metzler, M.; Wiemels, J.L.; Greaves, M.. 2004. "Protracted Postnatal Natural Histories in Childhood Leukemia". Genes Chromosomes and Cancer, 39 (4): 335-340. https://doi.org/10.1002/gcc.20003
Zuna, J.; Muzikova, K.; Ford, A.M.; Maia, A.T.; Krejci, O.; Tousovska, K.; Oravkinova, I.; Greaves, M.; Trka, J.. 2003. "Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets". Leukemia and Lymphoma, 44 (12): 2099-2102. https://doi.org/10.1080/1042819031000123393
Maia, A.T.; van der Velden, V.H.J.; Harrison, C.J.; Szczepanski, T.; Williams, M.D.; Griffiths, M.J.; van Dongen, J.J.M.; Greaves, M.F.. 2003. "Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins". Leukemia, 17 (11): 2202-2206. https://doi.org/10.1038/sj.leu.2403101
Greaves, M.F.; Maia, A.T.; Wiemels, J.L.; Ford, A.M.. 2003. "Leukemia in twins: Lessons in natural history". Blood, 102 (7): 2321-2333. https://doi.org/10.1182/blood-2002-12-3817
Maia, Ana-Teresa. 2003. "Molecular genetics and natural history of childhood leukaemia". Doutoramento.
Wiemels, J.L.; Xiao, Z.; Buffler, P.A.; Maia, A.T.; Ma, X.; Dicks, B.M.; Smith, M.T.; et al. 2002. "In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia". Blood, 99 (10): 3801-3805. https://doi.org/10.1182/blood.V99.10.3801
Maia, A.T.; Ford, A.M.; Reza Jalali, G.; Harrison, C.J.; Malcolm Taylor, G.; Eden, O.B.; Greaves, M.F.. 2001. "Molecular tracking of leukemogenesis in a triplet pregnancy". Blood, 98 (2): 478-482. https://doi.org/10.1182/blood.V98.2.478
 

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